Andrés and Paulina Treviño left everything behind in Mexico City in April, 2001, to bring their infant son Andy to Children’s Hospital Boston as a last resort. Here, immunologists discovered Andy suffered from a rare congenital disease, Primary Immune Deficiency. Prey to constant life-threatening infections, Andy’s only hope was a bone marrow stem cell transplant. The Treviños spent two years searching for a compatible donor in public registries around the world, then decided to try for a sibling match for Andy. Sister Sofia was born in March, 2004—a beautiful, healthy baby and a perfect match. Seven months later, Andy received Sofia’s umbilical cord and bone marrow stem cells, which, over time, helped rebuild his immune system. Today, Andy’s a healthy third-grader who loves baseball—and feels a special bond with his baby sister.


 
 
 

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Children's Hospital Boston Publications:
Spirit of Giving - Sister Savior (PDF Format) by Kate Kruschwitz
Dream Magazine - All for one by Matthew Cyr

Medical Journal Publications:
Finding Nemo: genetic disorders of NF-kB activation
by Jordan S. Orange and Raif S. Geha
Deficient natural killer cell cytotoxicity in patients with IKK-y/NEMO mutations by Jordan S. Orange et al.
The Presentation and Natural History of Immunodeficiency due to NFkB Essential Modulator Mutation by Jordan S. Orange et al.

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Boys with NEMO: - Brandon - Cameron - Conner - Cooper - Gavin - Giovanni - Jack - Jackson - Jacob - Justin - Keith - Rhys - Samuel - Simon



Contact email: andy [at] andy.org.mx
Voice: 1 617 8483958
Postal: 423 Brookline Ave. 149, Boston, Ma. 02215, USA

NEMO is a master switch that is found on the cytoplasm of the cell and regulates signals between the membrane and the nucleus. NEMO is expressed in almost all tissue cells. If NEMO is not present life is not possible. NEMO stands for Nuclear Factor Kappa B Essential Modifier. Nuclear Factor Kappa B or NFKB is the name of the protein that is used to communicate to the nucleus. The NEMO "master switch" is known to be the pathway of skin, skeleton, blood vessel and other vital signals.

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