David Baltimore (Nobel
Prize 1975) discovered the NEMO gene in 1980. NEMO comes from the words
Nuclear Factor Kappa B Essential Modifier.
NEMO is a "master switch" that is found on the cytoplasm and
regulates signals between the cell membrane and the cell nucleus. NEMO is
expressed in almost all tissue cells. If NEMO is not present life is not
possible. NEMO stands for Nuclear Factor Kappa B Essential Modifier. Nuclear
Faxtor Kappa B or NFKB is the name of the protein that is used to
communicate to the nucleus. The NEMO "master switch" is known to be the
pathway of skin, skeleton, blood vessel and other vital signals. For
example, the EDA gene is known to dictate properties of the "ectoderm" or
last layer of the skin. The EDA gene uses the NEMO pathway to the nucleus to
make the "ectoderm" properties present.
ARTICLES ABOUT NEMO
More information about NEMO on
ANDY BLOG.
Deficient natural killer cell
cytotoxicity in patients with IKK-/NEMO mutations
Jordan S. Orange, Scott R. Brodeur, Ashish Jain, Francisco A.
Bonilla, Lynda C. Schneider, Roberto Kretschmer, Samuel Nurko, Wendy L.
Rasmussen, Julia R. Köhler, Stephen E. Gellis, Betsy M. Ferguson, Jack L.
Strominger, Jonathan Zonana, Narayanaswamy Ramesh, Zuhair K. Ballas and Raif
S. Geha
The IKK/NF-κB pathway
Uwe Senftleben, MD; Michael Karin, PhD
Clinic of Anesthesiology, University of Ulm, Steinhövelstr. 9, 89075 Ulm,
Germany.
The National Human Genome Research
Institute
Lois E. Lander, MS
Information Specialist
X-linked anhidrotic ectodermal dysplasia with
immunodeficiency is caused by impaired NF-kappaB signaling. email
Döffinger R
Laboratoire de Génétique Humaine des Maladies Infectieuses, Faculté de
Médecine Necker-Enfants Malades, Paris, France.
03/2001 Nat Genet
Specific missense mutations in NEMO
result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia.
Jain A
Laboratory of Clinical Investigation, National Institute of Allergy and
Infectious Diseases, NIH, Bethesda, MD 20892, USA.
03/2001 Nat Immunol
Therapeutic potential of inhibition
of the NF-[kappa]B pathway in the treatment of inflammation and cancer
Yamamoto, Yumi; Gaynor, Richard B.
Division of Hematology-Oncology, Department of Medicine, Harold Simmons
Cancer Center, University of Texas Southwestern Medical Center, Dallas,
Texas, USA
01/2001 The Journal of Clinical Investigation
A novel X-linked disorder of immune
deficiency and hypohidrotic ectodermal dysplasia is allelic to intontinentia
pigmenti and due to mutations in IKK-gamma (NEMO).
Zonana J
Department of Molecular and Medical Genetics, Oregon Health Sciences
University, Portland, OR 97221, USA.
12/2000 Am J Hum Genet
NF-kappa B defects in humans: the
NEMO/incontinentia pigmenti connection. Courtois G
Unité de Biologie Moléculaire de l'Expression Génique, Institut Pasteur,
Paris, France.
11/2000 Sci STKE
Role of Drosophila IKK gamma in a
toll-independent antibacterial immune response.
Rutschmann S
Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.
10/2000 Nat Immunol
Isolation of full-length cDNA and
chromosomal localization of human NF-kappaB modulator NEMO to Xq28.
Jin DY
Molecular Virology Section, Laboratory of Molecular Microbiology, National
Institute of Allergy and Infectious Diseases, Bethesda, Md., USA.
03-04/1999 J Biomed Sci
Multiple pathogenic and benign
genomic rearrangements occur at a 35 kb duplication involving the NEMO and
LAGE2 genes.
Aradhya S
Department of Molecular and Human Genetics, Baylor College of Medicine, One
Baylor Plaza 902E, Houston, TX 77030, USA.
10/2001 Hum Mol Genet
