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Three options for treatment of Primary Immune
Deficiency:
a) Medications to prevent infections. To see a list of medications visit The
BLOG.
b) Stem cell transplant.
c) Genetic Therapy
STEM CELL TRANSPLANT
Blood stem cells produce all of your red blood cells, white
blood cells, and platelets. (Red blood cells carry oxygen to your organs and
tissues, white blood cells help protect the body from infection, and
platelets help to control bleeding). Stem cells are found in bone marrow or
blood, and also in the umbilical cord blood of newborn babies.
Each year, approximately 30,000 patients
in the U.S. will be diagnosed with leukemia and other life-threatening
diseases that can be treated with a stem cell transplant. Some of these
diseases include:
Various forms of leukemia
Congenital immune system disorders
Severe aplastic anemia
Hodgkin's disease
Non-Hodgkin's lymphoma
Patients are matched with stem cell donors
or cord blood units by comparing their HLA tissue types. HLA is the name
given to the system used to identify the unique markers (antigens) that the
immune system recognizes. These unique markers are found on virtually all
cells in the body, including white blood cells. In a stem cell transplant,
six HLA antigens are considered most important for matching: two A antigens,
two B antigens and two DR antigens.
HLA type is inherited through the genes
passed down from parents. The genes are linked together in strands of three:
three antigens from the mother and three from the father. To determine a
person's HLA type, the white blood cells are isolated from a blood sample
and testing is performed to identify which HLA markers are present.
ANDY'S HLA report:
ANDY 08.15.01
a) A3 B35 Bw6 Cw7 DRB1*1302 DQB1*06041 DRB3*0301
c) A3 B35 Bw6 Cw4 DRB1*1401/26 DQB1*05031 DRB3*0202
ANA PAULINA 09.13.01
a) A3 B35 Bw6 Cw4 DRB1*1401/26 DQB1*05031 DRB3
d) A2 B44 Bw4 Cw5 DRB1*1301/15/16 DQB1*06 DRB3
ANDRES 09.13.01
a) A3 B35 Bw6 Cw7 DRB1*1302/31 DQB1*06 DRB3
b) A24 B7 DRB1*1501/3 DQB1*06 DRB5
We're looking for a HLA compatible stem
cell donor for ANDY.
OUR QUESTIONS ABOUT THE STEM CELL TRANSPLANT
at the BLOG »
IMPORTANT LINKS »
STEM CELL THERAPY /
GENETIC THERAPY
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